/MY Comments are in Itiliacs/
Gene clues suggest autism strikes when brain can't learn properly from early life experiences
By LAURAN NEERGAARD | AP Medical Writer
10:16 AM EDT, July 14, 2008
WASHINGTON (AP) _ Harvard researchers have discovered half a dozen new genes involved in autism that suggest the disorder strikes in a brain that can't properly form new connections. Oh only If they knew autism like we do: autism is so simple, it is just the building blocks of the mind and not a bit of what we have figured out has been in a text book yet. That is why the "experts are so lost." Of course looking up to the 'stratosphere' for some magical autism gene is hopeless as our roots are below 123 and the ABCs. We connected MR/DD Autism to Einstein and even earned our social graces along the way. Old Crypto Sensitive Autism and those of us building on the work of Temple Grandin is mildly embarrassing for the new age Autism "professionals."
The findings also may help explain why intense education programs do help some autistic children — because certain genes that respond to experience weren't missing, they were just stuck in the "off" position. When all is said and done and the researchers finally know what we do, they can simply fill in the blanks like we do and they will see how the human mind works (for once) and how we overcame autism with a thought process they are not even aware of. Autism again, is the step by step one by one building block thoughts that normal minds do without a serious second thought. Once we learn our autism thoughts we can do normal thoughts. Autism is simply slow motion normal thoughts.
"The circuits are there but you have to give it an extra push," said Dr. Gary Goldstein of the Kennedy Krieger Institute in Baltimore, which wasn't involved in the gene hunt but is well-known for its autism behavioral therapy. Ever since the movie Rain Man and the designer Autism to follow it, autism is suddenly a "Disorder" a cause and a NASCAR race among many things. It is also a very good research career for way to many inept and seriously uncritqued autism researchers to get by. They can't even admit to the old working autism populations as we might well shatter their bubble. Autism was once non diagnosable and as such we thrived in a very odd childhood and education experience. MOST of us do normal, to the chagrin of Modern Autism. Our working mold is even blueprinted in the book the Enigma by Andrew Hodges (1983) Trust me if we supported their tale we would be "popular" and autism would have spilled its secrets by now. They only admit to the old autism folks that do group homes or a sheltered life. Working autism like we know and love does the impossible, normal lives. We invent things like computers, engines and even radio systems that run EMS services via Short Wave Radio from another country.
The genetics suggest that "what we're doing makes sense when we work with these little kids — and work and work and work — and suddenly get through," he said. It is via no effort of the researchers, If they had done their job and never forgot OLD crypto Sensitive autism guidelines they could be well versed in our lack of eye contact thought process that is now a days a DISORDER but in reality its our lifeline. In fact Autism really could be a simple 1-6 Grade Preschool if they knew what we knew, or even cared to listen and learn form the very "retards they are smarter than." They are researcher$, NOT listeners.
But the study's bigger message is that autism is too strikingly individual to envision an easy gene test for it. Instead, patients are turning out to have a wide variety, almost a custom set, of gene defects.
"Almost every kid with autism has their own particular cause of it," said Dr. Christopher Walsh, chief of genetics at Children's Hospital Boston, who led the research published in Friday's edition of the journal Science. Don't worry about the cause of it. When so many of us do the impossible-figure out Autism and do nearly normal lives (I CHALLENGE YOU) , do what we do connect autism to normal thoughts!
Autism spectrum disorders include a range of poorly understood brain conditions, from the mild Asperger's syndrome to more severe autism characterized by poor social interaction, impaired communication and repetitious behaviors. Its all the same stuff mate! There is little difference between the village idiot and the savant or the social autistic person. IF and that is a BIG IF autism knew what we did, they could simply teach us our autism thoughts that happen during the lack of eye contact in that 1-6 Th. grade school. We had to figure out our natural for us different mind set on our own just like today's Autistic people do as not one teacher or researcher has put even one of our thoughts up on a chalk board or in a book. Designer autism got a hold of the wrong end of the stick and took away our best chances at success-now they really do have an epidemic of self-inflicted ignorance on their hands and a billion dollar empire to keep funded.
It's clear that genes play a big role in autism, from studies of twins and families with multiple affected children. But so far, the genetic cause is known for only about 15 percent of autism cases, Walsh said.
So Walsh's team took a new tack. They turned to the Middle East, a part of the world with large families and a tendency for cousins to marry, characteristics that increase the odds of finding rare genes. They recruited 88 families with cousin marriages and a high incidence of autism, from Jordan, Saudi Arabia, Kuwait, Oman, Pakistan, Qatar, Turkey and the United Arab Emirates. They compared the DNA of family members to search for what are called recessive mutations — where mom and dad can be healthy carriers of a gene defect but a child who inherits that defect from both parents gets sick.
In some of the families, they found large chunks of missing DNA regions that followed that recessive rule. The missing regions varied among families, but they affected at least six genes that play a role in autism.
Here's why this matters: All the genes seem to be part of a network involved in a basic foundation of learning — how neurons respond to new experiences by forming connections between each other, called synapses.If they knew how our thought system worked and it was built they would drop all of this Gene stuff and simply be in awe at the very simple primitive human thoughts that we need to figure out BEFORE we can do normal thoughts like you use.
In the first year or two of life — when autism symptoms appear — synapses rapidly form and mature, and unnecessary ones are "pruned" back. In other words, a baby's brain is literally being shaped by its first experiences so that it is structurally able to perform learning and other functions of later life. What IF we are programed to Think in Pictures with the lack of eye contact thought process - BUT we are being taught your thought process and we are NOT ready for it. It is like expecting someone to learn to speak Spanish when trained you them in German, it is the same difference. All these Autism come lately autism researchers really think they are in the ballpark but the game was over before it even started. Really autism was pretty close to being figured out before the Movie Rain Man took it designer. What a shame we could add 1000s of pages to the psychology books and here modern autism spends all of its time going around a Race Track (Autism Speaks 400, NASCAR Race) and doing telethons. No wonder autism is an epidemic.
"This paper points to problems specifically in the way that experience sculpts the developing brain," explained Dr. Thomas Insel, director of the National Institute of Mental Health, which helped fund the work.
Some earlier research had pointed to the same underlying problem, so these newly found genes "join a growing list to suggest that autism is a synaptic disorder," he said.
If that sounds discouraging, here's the good news: The missing DNA didn't always translate into missing genes. Instead what usually was missing were the on/off switches for these autism-related genes. Essentially, some genes were asleep instead of doing their synapse work.
"I find that hopeful" because "there are ways that are being discovered to activate genes," Walsh said. "This might be an unanticipated way of developing therapies in the long term for autism: Identifying these kids where all the right genes are present, just not turned on in the right way." Autism worked much better in a time a space now too far out of the limelight to be admitted to. Besides the fact we do too much of a normal life and figured out a never in print thought process, we are the 'very retard' they are researching so therefore we are too stupid to have figured out our own conditions. Answer this, has any Autism researcher ever had an autism thought or even cared enough to interview those of us have been there and done that? When they discover our stories and see the Pandora's box of successful autism results they are more than willing to ignore us for the sake of autism's "future." (And their well being
At Kennedy Krieger, Goldstein thinks the work may provide a gene-level explanation for why some children already are helped by intense therapy.
"We have trouble getting through to these children, but with repeated stimulation we can do it," he said. "These are circuits that have an ability not so much to recover but to work around the problem." Ironically OLD autism did just that!— we worked around the problem enough to discover glimpses of normal thoughts and even if it took us 35 years to connect autism to normal thoughts. Modern autism could simply unite our anthropology and figure out what we know and make the 1 threw 6 Th. grade autism school from the result. That simple solution is mired in muck however as most of us that done autism so well are GLbt and when we drive and hold normal jobs and even present well we embarrass the modern autism empire to tears especially when it would be obvious they rewrote autism for their own benefit. Not all that we call progress is progress - 2008 Autism is a few $tep$ backwards! Rich Shull on the Blog Pre Rain Man Autism. I know these comments ruffle the feathers of a lot of readers but I will not apologize for figuring out my autism. Autism in my view was highjacked with good intention and has since been led astray. You must admit If autism research were sincere and honest it would have no trouble admitting to us, unless of course we embarrass them to death.
Rich is inventor of The Turing Motor a 70% Efficient Green triple hybrid car motor and author of autism's "worst book" Autism Pre Rain Man Autism a book built on Temple Grandin's Thinking in Pictures.
Labels: Future Horizons, politics and reality, Rimland, Verbal Talking Autism